Copy number variants in attention-deficit hyperactive disorder
نویسندگان
چکیده
منابع مشابه
Running head: ATTENTION DEFICIT HYPERACTIVE DISORDER 1 Attention Deficit Hyperactive Disorder: Pathophysiology, Pharmaclogical, and Nutrition Treatments
Attention deficit hyperactive disorder (ADHD) is one of the most common neurological disorders among children with approximately 5.4 million children diagnosed in the United Sates. Inattention and hyperactivity are two major symptoms associated with ADHD interfering with the ability to function well at school or work. The etiology of ADHD is very complex involving genetics, brain structure and ...
متن کاملBiological Overlap of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: Evidence From Copy Number Variants
OBJECTIVE Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share biological underpinnings. METHOD We compared copy number variant (CNV) data from 727 children with ADHD and 5,081 population controls to data from 996 individuals with ASD and an i...
متن کاملGlutamatergic copy number variants and their role in attention-deficit/hyperactivity disorder.
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with a strong genetic component. The glutamate metabotropic receptor genes (GRMs) have been considered potential candidates for ADHD susceptibility. The aim of the present study was to investigate if copy number variants (CNVs) in GRM1, GRM5, and GRM8 genes are overrepresented in ADHD subjects. A total of 10...
متن کامل[Nutritional aspects of attention-deficit/hyperactive disorder].
INTRODUCTION Attention-deficit/hyperactive disorder (ADHD) has received in the past years a lot of attention from the paediatrician's specialties. Even though the studies of its etiopathology have advanced, mainly the ones related with genetics and neuroimaging, the final cause today is still unclear. DEVELOPMENT It has been related to many factors such as diet, like some allergies to additiv...
متن کاملClinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants
BACKGROUND Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases. AIMS To identify whether large, rare CNVs in attention-deficit hyperactivity disorder (ADHD) are confined to a distinct clinical subgroup. METHOD A total of 567 children with ADHD aged 5-17 years were recruited fr...
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ژورنال
عنوان ژورنال: Psychiatric Genetics
سال: 2015
ISSN: 0955-8829
DOI: 10.1097/ypg.0000000000000056